Cyclin Dependent Kinase 5 (Cdk5)

This book provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5. It further reviews the potential implication of Cdk5 in the treatment of neurodegenerative diseases.

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Will appeal to researchers from various fields of neuroscience research, in light of the extensive involvement of Cdk5 in neuronal development, plasticity and neurological disorders Written by leaders in the field of Cdk5 research Will encompass a variety of Cdk5 studies using different approaches to elucidate the functions and signaling mechanisms of Cdk5

Klappentext

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

Inhalt
Cdk5/p35 Regulates Neuronal Migration.- CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration.- Cdk5 in Presynapses.- Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release.- Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling.- Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival.- CDK5 and Mitochondrial Cell Death Pathways.- Regulation and Function of Cdk5 in the Nucleus.- Cdk5 May Be an Atypical Kinase, but Not in the Way You Think.- Cdk5 and Neuregulin-1 Signaling.- Cyclin-Dependent Kinase 5 and Insulin Secretion.- ProteinProtein Interactions Involving the N-Terminus of p35.- The Kinase Activity of Cdk5 and Its Regulation.- The Structural Bases of CDK5 Activity.- Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting.- Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory.- Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration.- Cdk5 as a Drug Target for Alzheimer's Disease.