Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease

This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.

Zusammenfassung
Proceedings of an International Symposium held in New Orleans, Louisiana, October 28, 1997

Inhalt
I: Neuronal Metabolism and Cytochrome Oxidase Function.- 1. Brain Cytochrome Oxidase: Functional Significance and Bigenomic Regulation in the CNS.- 2. Quantitative Histochemistry of Cytochrome Oxidase Activity: Theory, Methods, and Regional Brain Vulnerability.- 3. Cytochrome Oxidase and Neuroanatomical Patterns: What Is the Connection?.- 4. Functional Mapping of Learning-Related Metabolic Activity with Quantitative Cytochrome Oxidase Histochemistry.- 5. Functional Imaging Probes to Study the Neural Bases of Behavior in Genetic Animal Models of ADHD: A Comparative Analysis of Short and Long-Term Markers of Neuronal Activity.- II: Alzheimer's Disease and Cytochrome Oxidase Dysfunction.- 6. Cytochrome Oxidase Inhibition in Alzheimer's Disease.- 7. Molecular Mechanisms of Impaired Mitochondrial Gene Expression in Alzheimer's Disease.- 8. Behavioral, Electrophysiological, and Biochemical Consequences of Chronic Cytochrome Oxidase Inhibition in Rats.- 9. Cytochrome Oxidase: A Predictive Marker of Neurodegeneration.- III: Appendix.- 10. Cytochrome Oxidase Atlas of Rat Brain.- Contributors.