Design and Development of tablets for the treatment of blood pressure

Metoprolol tartrate, a nonselective beta adrenergic blocking agent, is widely used in the treatment of hypertension, angina pectoris and many other cardiovascular disorders. The bioavailability of Metoprolol tartrate is low. Metoprolol tartrate is highly water soluble drug with relatively short biological half-life of 4-5 hrs and usual dose is 25 mg thrice daily. This demands high frequency of administration resulting in oscillation of plasma drug concentration, it is necessary to develop sustained release dosage form with extended clinical effect.Metoprolol Tartrate was formulated as immediate release layer as well as sustained release layer.

Autorentext

Dr.Vikram M. Pandya is an Associate Professor at B.S.Patel Pharmacy College, Linch-Mehsana -384 435, Gujarat, India. He has more than 11 years of academic and Industrial experience, has published 30 research and review papers in various international and national journals. Dr. Pandya has guided 17 M.Pharm students for research work.