DEVELOPMENT OF CLOTRIMAZOLE EMULGEL

Clotrimazole is an imidazole derivative with a broad spectrum of anti-mycotic activity. The Present investigation is the design and characterization of Novel Emulgel of Clotrimazole. Nine different formulations of Emulgel were prepared by the proposed method of preparation by Mohammad et.al (2004), varying with different 2 different polymers of gelling agent such as Carbopol 934 and HPMC K15 M and their combinations in different ratios. All the Formulations were characterized for physical evaluation, drug content, Viscosity,spreadability, extrudability, and In-vitro Drug release studies. Stability studies were revealed with marginal differenceswith a good stability. Also this study refers to the kinetic data of the drug release studies.

Autorentext

P. N. Mallikarjun is working as Associate Professor in Vignan Institute of Pharmaceutical Technology, Duvvada,Visakhapatnam, Andhra Pradesh, India. He has academic experience of 18 years and guide more than 20 projects.