Diabetic Bone Disease

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

A comprehensive presentation of the current research and treatment for skeletal deficits and complications due to diabetes type 1 and 2 Covers epidemiology, fracture risk assessment, biomarkers, biomechanics, bone quality, and the safety and efficacy of anti-diabeteic therapy on bone health An excellent resource for endocrinologists and orthopedists alike Includes supplementary material: sn.pub/extras

Autorentext

Beata Lecka-Czernik, PhD, Professor, Department of Orthopedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Health Sciences Campus, Toledo, OH, USA

John L. Fowlkes, MD, James Hamlen Professor of Pediatrics, Vice-Chair for Research, Section Chief, Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA

Inhalt

Part I: Clinical and Pre-clinical Applications and Research.- Skeletal deficits in Type 1 Diabetes Mellitus- Skeletal Deficits in Type 2 Diabetes Mellitus.- Fracture Risk Assessment in Diabetes.- Diabetes-related Conditions and Complications in Orthopedic Surgery.- Impact of Diabetes on Periodontal Disease.- Biomarkers of Diabetic Bone Disease.- Safety of Anti-diabetic Therapies on Bone.- Bone Marrow Stem Cells and Bone Turnover in Diabetic Disease.- Part II: Biomechanics and Bone Quality.- Material Properties of Diabetic Bone.- Bone Quality in Type 2 Diabetes Mellitus.- Imaging of Diabetic Bone Structure.