Digestive neuroendocrine tumors

Digestive neuroendocrine tumors (DNETs) are rare (less than 1% of malignant tumors). They are a heterogeneous group of tumors with common functional and morphological characteristics. In practice, a distinction is made between endocrine tumors of the digestive tract, pancreatic endocrine tumors and hepatic endocrine tumors. The circumstances in which these tumors are discovered vary, depending on whether or not they are functional. Carcinoid syndrome is the characteristic clinical manifestation of these tumors. It is triggered by the tumor's release of serotonin and other peptides (bradykinin, histamine, substance P, etc.). It occurs in only 10-20% of patients, mainly when liver metastases are present. It typically associates flushing and motor diarrhea. Carcinoid cardiopathy may be present after a long period of evolution in around a third of cases.

Autorentext

Docteur Wala BEN KRIDIS est Maitre de Conférence Agrégé à la Faculté de Médecine de Sfax (Tunisie).Diplômée en carcinologie médicale (MD)Diplômée en science biologiques(PhD)Mastère de recherche clinique en sciences médicales *Certificat d'études complémentaires de Bases fondamentales en pédagogie.