Diseases of the Human Carotid Body

Ever since its discovery in 1742 the carotid body has remained an organ of mystery. Originally described as a ganglion, it was subsequently regarded as a gland, chromaffin paraganglion and non-chromaffin paraganglion. In 1928 it was shown to be a chemoreceptor with close associations with the function of baroreception in the adjacent carotid sinus and perhaps within its own substance. These discoveries led physiologists to embark on a series of elegant experimental studies on a number of animal species which have, however, so far failed to identify the transducer for detection of changes in tension of arterial blood gases or the mechanism of chemor eception. Pathologists on the other hand have largely ignored the carotid body, restricting their interest to its tumour, the chemodectoma. A remarkable disparity in knowledge of the organ has resulted, with most information being available on the physiology of chemoreceptor tissue in laboratory animals. In contrast, there has been sparse interest and awareness of the pathology in man of this nodule of tissue lying in the carotid bifurcation whose functional activity is suggested by the high blood flow it receives, and its rich content of biogenic amines and a wide variety of peptides. This book is an attempt to redress this unsatisfactory situation. During the last few years our understanding of the detailed histology and ultrastructure of the human carotid body has improved.

Klappentext

This highly original volume with its unique comprehensive coverage of diseases of the human carotid body results from the authors' 20 years research into the subject and is destined to become a classic.

Inhalt
1 The Nature of the Carotid Body.- 2 Size, Weight and Anatomical Variation.- 3 Normal Histology.- 4 Histological Changes Associated with Ageing of the Adult Carotid Body.- 5 The Carotid Bodies in Fetuses, Neonates and Infants.- 6 Chronic Carotid Glomitis.- 7 Physiology.- 8 Peptides.- 9 The Carotid Bodies in Hypoxaemia.- 10 Carotid Body Hyperplasia.- 11 The Carotid Bodies at High Altitude.- 12 Ventilation and the Carotid Bodies.- 13 Almitrine.- 14 The Carotid Bodies in Systemic Hypertension.- 15 The Carotid Bodies and Sodium Metabolism.- 16 The Glomic Vasculature.- 17 Normal Ultrastructure.- 18 Ultrastructure of the Hypoxic and Hyperplastic Carotid Body.- 19 Chemodectomas.- 20 Carotid Sinus.- 21 Comparative Histopathology.