DNA Nanotechnology

This book begins with basic information and moves on to cover design and fabrication of static and dynamic DNA nanostructures, advances in DNA origami, DNA walkers and nanodevices, and applications including biosensing, computation, drug delivery and more.

DNA nanotechnology: From structure to function presents an overview of various facets of DNA nanotechnology, with a particular focus on their promising applications. This book is composed of three parts. Part I, Elements of DNA Nanotechnology, provides extensive basic information on DNA nanotechnology. Part II, Static and Dynamic DNA Nanotechnology, describes the design and fabrication of static and dynamic DNA nanostructures. Recent advances in DNA origami, DNA walkers and DNA nanodevices are all covered in this part. Part III, Applications of DNA Nanotechnology, introduces a variety of applications of DNA nanotechnology, including biosensing, computation, drug delivery, etc. Together these provide a comprehensive overview of this emerging area and its broad impact on biological and medical sciences.

This book is intended for post-graduates, post-doctoral researchers and research scientists who are interested in expanding their knowledge of DNA nanotechnology. It provides readers an impression of the latest developments in this exciting filed.

Offers a comprehensive overview of DNA nanotechnology and its promising applications Provides easy-to-use toolboxes for DNA nanotechnology Written by active scientists working at the cutting edge of this highly interdisciplinary filed

Autorentext

Prof. Chunhai Fan received his PhD (2000) from Department of Biochemistry, Nanjing University. From 2001 to 2003, he was a postdoctoral fellow with Prof. Alan J. Heeger at the University of California, Santa Barbara. In 2004, he became a Professor at Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences (CAS). Currently he is the Professor and Chief of the Division of Physical Biology at the same institute.
Prof. Fan's research interests include nanoscale biosensors, biophotonics and DNA nanotechnology. He has published over 200 papers in peer-reviewed journals and has written numerous reviews in premier journals including Accounts of Chemical Research, Chemical Society Reviews and Trends in Biotechnology. He has received many awards including the NSFC Award for Outstanding Young Scientists (National Science Foundation of China), the CCS Award for Young Scientists (Chinese Chemical Society) and the CAIA 1st-class Prize for Science and Technology (Chinese Association for Instrumental Analysis).

Inhalt

Part I Elements of DNA Nanotechnology.-

Brief History of DNA Nanotechnology.- Functional Nucleic Acids for DNA Nanotechnology.- Selenium Atom-Specific Mutagenesis (SAM) for Crystallography, DNA Nanostructure Design, and Other Applications.- Liposomes for DNA Nanotechnology: Preparation, Properties and Applications.- Manipulation and Isolation Individual DNA Molecules with Atomic Force Microscope.- Single Molecule Mechanics of DNA.- Microfluidic Tools for DNA Analysis.-

Part II Static and Dynamic DNA Nanotechnology.-

DNA-Directed Assembly of Nanophase Materials: An Updated Review.- Self-Assembled DNA-Inorganic Nanoparticle Structures.- DNA Origami Nanostructures.- Design, Fabrication and Applications of DNA Nanomachines.- DNA Walking Devices.-

Part III Applications of DNA Nanotechnology.-

Functional DNA Integrated Nanomaterials for Biosensing.- Nucleic Acid Enzymes-Based DNA Nanomachine for Biosensing.- DNA Nanotechnology and Drug Delivery.- DNA-Nanotube-Enabled NMR Structure Determination of Membrane Proteins.- Deoxyribozyme-Based Molecular Computation.