Double layer disc for treatment of diabetes

The present research work was carried out to develop a Bilayer tablet of M.HCl as ER layer and Acarbose as IR layer from their respective SDs. Eudragit RL 100 and RS 100 were used for the preparation of SD of M.HCl enables drug release for upto 12 hrs. Among the different formulations, formulation having Eudragit RL 100 and RS 100 in the ratio of 1:2 (MF8) can be preferred as integrity was maintained. PVP K 30 and PEG 6000 were used for the preparation of SD of Acarbose. Among the different formulations, formulation having Acarbose and PVP K 30 in the ratio of 1:4 (AF3) can be preferred because of maximum drug release and highest correlation coefficient. The analysis by spectral technique (FT-IR) suggested the possibility of hydrogen bonding.

Autorentext

Dr. Ruchi Tiwari is an Associate Professor in Department of Pharmaceutics at the Pranveer Singh Institute of Technology, Kanpur. She has more than 8 books and 13 patents to her credit.