Drug Delivery Systems

This third edition volume expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and thorough, Drug Delivery Systems: Methods and Protocols, Third Edition is a valuable resource for scientists working in industry or academia, and physicians involved in research and clinical care of patients.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
An Overview of Drug Delivery Systems.- Role of Nanobiotechnology in Drug Delivery.- Intrathecal Drug Delivery.- Microanatomy Relevant to Intrathecal Drug Delivery.- Drug Delivery Applications of Nanoparticles in the Spine.- Synthesis of Gold Nanoparticle: Peptide Drug Conjugates for Targeted Drug Delivery.- A Method for Targeted Non-Viral siRNA Delivery in Cancer and Inflammatory Diseases.- Tumor-Targeted Dendrimer Nanoparticles for Combinatorial Delivery of siRNA and Chemotherapy for Cancer Treatment.- Sonoporation for augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma.- Preparation of Cholera Toxin Subunit B Functionalized Nanoparticles for Targeted Therapy of Glioblastoma.- Microfluidic-Manufacturing of Multi-Targeted PLGA/PEG Nanoparticles for Delivery of Taxane Chemotherapeutics.- Computer-Aided Design of Nanoparticles for Transdermal Drug Delivery.- Microneedle Mediated Transdermal Delivery of Tizanidine Hydrochloride.- Targeted siRNA Delivery using Lipid Nanoparticles.- Lipid Nanocarriers for Enhanced Delivery of Temosolomide to the Brain.- Construction of a Macrophage-Targeting Bio-Nanocapsule-Based Nanocarrier.