Early Life Origins of Health and Disease

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a 'must' for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the 'optimal' way in which to investigate these phenomena.

Presents a very up-to date and readable summary of our current understanding of the importance of life before birth, from conception to delivery, and in infancy and childhood, on the subsequent health of the person The authors are among the world experts in the areas covered Presents critical analysis of experimental paradigms and methodologies and the authors define, for all types of data collection/experimentation, the methods that should be used as 'world's best practice' Contains chapter summaries and detailed illustrations Includes supplementary material: sn.pub/extras

Autorentext

Professor Owens is an internationally recognized researcher in developmental physiology and endocrinology and in the early life programming of adult health and disease, diabetes and obesity in particular. She has published over 140 research papers, reviews and book chapters. She has been invited to present numerous plenary lectures or symposia at international or national conferences, and to convene and chair international symposia and plenary sessions at the First, Second and Third World Congresses for the Developmental Origins of Adult Health and Disease (previously Fetal Origins of Adult Disease). She was awarded the McCance Medal for outstanding contributions to perinatal research.

Inhalt
The Developmental Origins of Health and Disease.- The Developmental Origins of Health and Disease.- Should we intervene to improve fetal growth?.- Developmental Origins of Cardiovascular Disease, Type 2 Diabetes and Obesity in Humans.- Growth and development of human twins.- Studies of Twins.- Practice-induced plasticity in the human motor cortex.- Prenatal Programming of Human Motor Function.- Adaptive Responses of Early Embryos to Their Microenvironment and Consequences for Post-Implantation Development.- Adaptive Responses of Early Embryos to Their Microenvironment and Consequences for Post-Implantation Development.- Modification of Epigenetic State through Dietary Manipulation in the Developing Mammalian Embryo.- Modification of Epigenetic State through Dietary Manipulation in the Developing Mammalian Embryo.- Overview of epigenetic mechanisms.- Critical Experiments to Determine if Early Nutritional Influences on Epigenetic Mechanisms Cause Metabolic Imprinting in Humans.- Nutritional programming and the development of hypertension.- Manipulation of the Maternal Diet in Rat Pregnancy.- Hypertension in pregnant women.- Programming HypertensionAnimal Models.- Developmental Programming of Cardiovascular Dysfunction.- Developmental Programming of Cardiovascular Dysfunction.- Kidney Development and Fetal Programming.- Kidney Development and Fetal Programming.- Programming of ObesityExperimental Evidence.- Programming of ObesityExperimental Evidence.- Placental delivery of amino acids. Utilization and production vs. transport.- Perinatal Programming of Adult Metabolic Homeostasis.- Programming Effects of Excess Glucocorticoid Exposure in Late Gestation.- Programming Effects of Excess Glucocorticoid Exposure in Late Gestation.- Emerging Frontiers.- ProgrammingEffects of Moderate and Binge Alcohol Consumption.- Vitamin D in Pregnancy and Offspring Health.- The Fetal Origins of Adult Mental Illness.- Hypoxia, Fetal Growth and Developmental Origins of Health and Disease.