Electrical Brain Stimulation: Mechanisms and Modulation of Neuronal Activity

This open access book explores the mechanisms and modulation of invasive neural electrical stimulation in the brain. Drawing from the author's extensive research experience, it offers in-depth yet accessible content, enriched with vivid illustrations and practical applications. Notably, the book provides detailed techniques for animal experiments and methods for recording and processing neural electrical signals with a depth rare in similar works. The book is divided into two parts. Part I introduces fundamental electrophysiological theories and experimental methods. It covers the basic electrical properties of neuronal membranes, the famous Hodgkin-Huxley mathematical model, hippocampal neural networks and electrically evoked potentials, in-vivo rat experimental methods and equipment, and techniques for recording and processing neural electrical signals. Part II focuses on neural modulation through various electrical stimulations. It examines how various patterns of high-frequency pulse stimulations affect individual neurons, neuronal populations, and neural networks. In addition to exploring neuronal responses to electrical stimulation under normal physiological conditions, this part also investigates the inhibitory effects of high-frequency stimulation on epileptiform activity. This comprehensive book can serve as a valuable reference for researchers, teachers, students, and enthusiasts in the fields of neurophysiology, neural signal analysis, neural engineering, neuromodulation, brain stimulation, and brain-computer interfaces. It also provides excellent supplementary material for undergraduate and graduate courses in biomedical signal processing, neural engineering, and neuroscience.

This book is open access, which means that you have free and unlimited access Provides detailed rat experimental techniques and signal processing methods accompanied by vivid illustrations Presents a series of novel findings on neuronal responses to invasive brain electrical stimulations Offers valuable insights for researchers in fields such as brain stimulation,neural engineering,brain-machine interfaces

Autorentext

Zhou-Yan Feng is a professor in the College of Biomedical Engineering and Instrument Science at Zhejiang University, China. She completed all her education at Zhejiang University, earning Bachelor's (1986), Master's (1989), and Doctoral (2001) degrees in Biomedical Engineering. After joining the faculty in 1989, she was promoted to associate professor in 1996 and full professor in 2006. From 2002 to 2004, she worked as a visiting scholar at the Neural Engineering Center at Case Western Reserve University, USA. Her main research areas include neural electrical stimulation, biomedical signal processing, and medical instrumentation. She has published over 100 articles, one monograph, and more than ten book chapters and translated works.

Inhalt

Fundamentals of Neuro-electrophysiology.- Neural Circuits and Evoked Potentials.- Experimental Methods and Setup.- Neural Signal Recording and Processing.- Neuronal Responses to Axonal High-Frequency Pulse Stimulations.