Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators

Promotes the understanding and application of extended immune checkpoint regulators

Offers new strategies for the therapy of various diseases, such as autoimmune diseases and cancer

Autorentext

Akihiko Yoshimura, PhD
Department of Microbiology and Immunology,
Keio University School of Medicine
35 Shinanomachi, Shinjyuku-ku, Tokyo
160-8582, Japan
Phone: +81-3-5363-3483
FAX: +81-3-5360-1508

yoshimura@a6.keio.jp

Inhalt

Regulatory T cells: molecular and cellular basis for immunoregulation.- Overview of LAG-3- expressing, IL-10-producing regulatory T cells.- Regulatory Dendritic Cells.- Role of PD-1 in immunity and diseases.- CTLA-4, an essential immune-checkpoint for T cell activation.- Tim-3, Lag-3, and TIGIT.- SOCS1: regulator of T cells in autoimmunity and cancer.- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity.- Immune regulation by ubiquitin tagging as checkpoint code.- MicroRNA in Immune Regulation.