Endocrine Disruptors and Puberty

Reviewing basic biology, molecular mechanisms of endocrine disruption and more, this book focuses on the effects of endocrine disruptors on the female and male reproductive systems, including thyroid and metabolism at all developmental stages of puberty.

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

First text to focus exclusively on the effects of endocrine disruptors in regard to puberty Comprehensive, covering basic biology of endocrine disruptors through definition and classification of endocrine disruptors, physicochemical properties, environmental distribution, and clinical consequences Discusses molecular mechanisms of endocrine disruption and endocrine disruptors in the developing organism including the neuroendocrine hypothalamic-pituitary-gonadal targets of developmental exposure to endocrine disruptors Addresses developmental exposure to endocrine disruptors and consequent adverse female and male reproductive outcomes Details developmental exposure of endocrine disruptors on thyroid dysregulation and on metabolism, as well as key issues involved in the way endocrine disruptors are discussed in the public health arena Includes supplementary material: sn.pub/extras

Inhalt

Introduction to endocrine disruptors and Puberty.- In utero exposure to environmental chemicals - Lessons from maternal cigarette smoking and its effects on gonad development and puberty.- Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors.- Endocrine disruptors and puberty disorders from mice to men (and women).- Thyroid hormone regulation of mammalian reproductive development and the potential impact of endocrine disrupting chemicals.- Developmental exposure to endocrine disruptors and ovarian function.- Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development.- Developmental exposure to endocrine disruptors and male urogenital tract malformations.- EDC exposures and the development of reproductive and non-reproductive behaviors.- Adipocytes as target cells for endocrine disruption.- Altered Glucose Homeostasis Resulting From Developmental Exposures To Endocrine Disruptors.- Developmental Exposure to Endocrine Disrupting Chemicals: Is there a Connection with Birth and Childhood Weights?.- The Impact Of Endocrine Disruptors On Female Pubertal Timing.- The influence of endocrine disruptors on Male Pubertal Timing.- Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure?.