Endoscopic and Second Harmonic Optical Coherence Tomography

Optical coherence tomography (OCT) is a
noninvasive, noncontact imaging modality that uses
coherent gating to obtain high-resolution
cross-sectional images of tissue microstructure.
This book focuses on endoscopic OCT diagnosis.
Because of high-resolution ability of OCT technology,
its endoscopic diagnosis aims to perform optical
biopsy without damaging the tissue, detect early
stage diseases and monitor the healing effect after
surgery. The organs such as human vessel, vocal
cord, gastrointestinal track and airway are
investigated. In order to access these organs, four
OCT endoscopes are designed to deliver infrared light
to the region of interest.
Additionally, a second harmonic spectrometer based
OCT is designed to increase OCT image contrast. With
the contrast enhancement from second harmonic
generation, the structure of highly organized tissue,
like collagen, is obtained. This information is
complementary to the standard OCT. Second harmonic
OCT has the potential to provide molecular contrast
for in vivo clinical application.

Autorentext

Mr.Su received his PH.D. degree of Biomedical engineering inIrvine,Univ. of California,USA and master degree of EngineeringPhysics in Tsinghua Univ., China. His research focus on OpticalConherece Tomography.

Klappentext

Optical coherence tomography (OCT) is anoninvasive, noncontact imaging modality that usescoherent gating to obtain high-resolutioncross-sectional images of tissue microstructure. This book focuses on endoscopic OCT diagnosis. Because of high-resolution ability of OCT technology,its endoscopic diagnosis aims to perform "opticalbiopsy" without damaging the tissue, detect earlystage diseases and monitor the healing effect aftersurgery. The organs such as human vessel, vocalcord, gastrointestinal track and airway areinvestigated. In order to access these organs, fourOCT endoscopes are designed to deliver infrared lightto the region of interest. Additionally, a second harmonic spectrometer basedOCT is designed to increase OCT image contrast. Withthe contrast enhancement from second harmonicgeneration, the structure of highly organized tissue,like collagen, is obtained. This information iscomplementary to the standard OCT. Second harmonicOCT has the potential to provide molecular contrastfor in vivo clinical application.