Endothelial Cell Dysfunctions

Noted experts survey and evaluate the latest research in the growing field of endothelial cell involvement in the initiation and development of various diseases. Research-oriented chapters span a diversity of topics, including endothelial cell response to various injuries and its crucial role in inflammation, immunity, viral infection, hypertension, hyperlipidemia, atherosclerosis, diabetes mellitus, neoplasia, and metastasis.

Inhalt
I. General.- 1. Endothelial Cell Response to Normal and Abnormal Stimuli: Modulation, Dysfunction, Injury; Adaptation, Repair, Death.- 2. Interactions of Matrix Components and Soluble Factors in Vascular Cell Responses to Injury: Modulation of Cell Phenotype.- 3. Endothelial Cell Regrowth.- 4. Modulation of Fibronectin and Thrombospondin Synthesis and mRNA Levels by Heparin in Human Endothelial and Smooth Muscle Cell Cultures.- 5. Dysfunction of the Release of Endothelium-Derived Relaxing Factor.- 6. Modulation of Endothelial Paracellular Permeability: A Mechanistic Approach.- II. Endothelial Cell in Inflammation and Immunity.- 7. Endothelial-Leukocyte Adhesion Molecules in Acute Inflammation and Atherogenesis.- 8. Leukocyte-Mediated Endothelial Injury.- 9. Endothelial Cell Adhesive Interactions: Mechanisms and Consequences.- 10. Modulation of Endothelial Cell Proliferation by Monocyte-Derived Cytokines.- 11. Recent Insights into the Mechanisms of Vascular Injury: Implications for the Pathogenesis of Vasculitis.- 12. The Role of Endothelium in the Pathophysiology of Rheumatoid Inflammation.- 13. Mechanisms of Neutrophil Migration across Endothelium.- 14. Endothelial Permeability in Inflammation: The Role of Capillaries versus Venules.- III. Endothelial Cell in Viral Infections.- 15. Response of Human Vascular Cells to Viral Infection.- IV. Endothelial Cell in Hypertension, Hyperlipidemia, and Atherosclerosis.- 16. Changes of Arterial Endothelial Cells in Chronic Hypertension with Special Reference to Regressive Changes and Replication.- 17. Specific Platelet Mediators and the Abrupt Progression of Coronary Artery Stenoses: Experimental Evidence and Potential Clinical Implications.- 18. Endothelial Dysfunction and Atherosclerosis.- 19. Artery Wall Interactions in Early Atherogenesis.- 20. Endothelial Cell Dysfunction and Injury in Experimental Hyperlipidemic Atherogenesis.- V. Endothelial Cell in Diabetes.- 21. Brain Capillary Endothelial Transport of Insulin.- 22. Vascular Endothelium and Diabetes Mellitus.- 23. Cellular and Molecular Mechanism of Glucose-Induced Diabetic Microangiopathy.- VI. Endothelial Cell in Neoplasia and Metastasis.- 24. Role of the Vascular Endothelium in Cancer Metastasis.- 25. Endothelial Cell Heterogeneity: Its Role as a Determinant of Selective Metastasis.- 26. Organotypic Endothelial Cell Surface Molecules Mediate Organ Preference of Metastasis.- 27. The Microvascular Phases of Metastasis.- 28. Possible Relationship between Vascular Permeability Factors, Endothelial Cells, and Peritumoral Brain Edema: A Neurosurgeon's Perspective.- VII. Endothelial Cell in Other Disturbances.- 29. Effects of Polyunsaturated Fatty Acids in Endothelium.- 30. Modulation of Endothelial Coagulant Properties and Barrier Function by Factors in the Vascular Microenvironment.- 31. Parathyroid Endothelium: A New Look at the Pathophysiology of Idiopathic Hypoparathyroidism.