Engineering Translational Models of Lung Homeostasis and Disease

Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners.

Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges arehighlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science.

· Each section focuses on a specific region of the lung, presenting either the biological or clinical perspective along with complimentary engineering approaches

· Covers the interface of engineering and lung biology

· Highlights emerging new models to study lung disease and repair

Chapter 4 is available openaccess under a Creative Commons Attribution 4.0 International License via link.springer.com

Each section focuses on a specific region of the lung and presents both the biological & clinical perspective Covers the interface of engineering and the lung between lung physiology and engineering Highlights emerging new models to study lung stem cells and regeneration

Autorentext
Dr. Chelsea Magin is an Assistant Professor in the Department of Bioengineering, Department of Pediatrics, and the Division of Pulmonary Sciences and Critical Care Medicine in the Department of Medicine at the University of Colorado, Denver | Anschutz Medical Campus. Dr. Magin leads a laboratory that engineers biomaterials for translational studies of lung disease and repair.

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