Enzyme Cascade Design and Modelling

This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.

Creates the basis for pathway design via the concept of 'biocatalytic retrosynthesis' Enhances the readers' understanding on kinetic modelling and reaction engineering Introduces process design, process modelling, monitoring and control of catalytic cascades Discusses both multi-enzymatic and chemo-enzymatic cascades Provides an outlook on industrial applications and future developments

Autorentext

Prof. Dr. Selin Kara, Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark Assoc. Prof. Dr. Florian Rudroff, Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria

Inhalt
Preface.- Chapter 1: Introduction.- Chapter 2: Enzyme Cascade Design Retrosynthesis Approach.- Chapter 3 : Multi-Enzymatic Cascades in vitro.- Chapter 4: Multi-Enzymatic Cascades in vivo.- Chapter 5: Chemo-Enzymatic Cascades.- Chapter 6: Enzyme Cascade Kinetic Modelling.- Chapter 7: Enzyme Cascade Reaction Engineering.- Chapter 8: Enzyme Cascade Process Design and Modelling.- Chapter 9: Enzyme Cascade Reaction Monitoring And Control.- Chapter 10: Cascade reactions in non-conventional media.- Chapter 11: Perspectives.