Epigenetic Mechanisms in Cellular Reprogramming

Offering an overview of current topics and concepts concerning mechanisms and consequences of epigenetic reprogramming, this book addresses biomedical researchers in search of more detailed knowledge of novel mechanisms and methods of study.

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.

Contains translational medicine aspects such as B cell programming and reprogramming in cancer Includes extensive glossary Understanding stem cell formation is key to develop novel drugs

Autorentext
Jörn Waltergeb. 1957 in Bremen. 1976 bis 1982 Raumplanungsstudium an der Universität Dortmund.1982 bis 1984 Städtebaureferendariat in Düsseldorf. 1985 bis 1991 Leiter des Stadtplanungsamtes für Stadtentwicklung und Umwelt der Stadt Maintal. 1991 bis 1999 Leiter des Stadtplanungsamtes Dresden. Seit 1999 Oberbaudirektor der Freien und Hansestadt Hamburg. 1997 Gastprofessur für städtebauliches Entwerfen an der Technischen Universität Wien. 2001 Professor an der Hochschule für bildende Künste, Hamburg. Mitglied der Deutschen Akademie für Städtebau und Landesplanung, der Akademie der Künste Berlin-Brandenburg und der Sächsischen Akademie der Künste.

Inhalt

Stella and zygotic reprogramming by Toshinobu Nakamura and Toru Nakano.- Histone variants and reprogramming in early development by Ana Bokovi and Maria-Elena Torres-Padilla.- Epigenetic regulation of pluripotency by polycomb group proteins by Achim Breiling.- PRC1-mediated gene silencing in pluripotent ES cells: function and evolution by Matthias Becker, Nancy Mah, Daniela Zdzieblo, Xiaoli Li, Arvind Mer, Miguel A. Andrade-Navarro, and Albrecht M. Müller.- The Biology and Genomic Localisation of Cytosine Modifications by Gordon R. McInroy, Neil M. Bell, Gabriella Ficz, Shankar Balasubramanian, Wolf Reik and Eun-Ang Raiber.- DNA methylation reprogramming in preimplantation development by Konstantin Lepikhov, Julia Arand, Sarah Fuchs, Jie Lan, Mark Wossidlo, and Jörn Walter.- Epigenetic reprogramming in cancer by Anders M. Lindroth, Yoon Jung Park, and Christoph Plass.- Establishing and Maintaining Pluripotency- An Epigenetic Perspective by Jing Liao and Alexander Meissner.- Glossary