Epigenetics of Cervical Cancer

This book focuses on the fundamentals of epigenetics, covering the roles of DNA methylation, histone modifications, and non-coding RNA, especially miRNA and lncRNA, in cervical cancer. The chapters discuss various methods to detect epigenetic changes and how these changes could be useful for diagnosis, prognosis, as well as epigenetic therapy. Further chapters address the up-to-date approaches and solutions to the parameterizing bottlenecks associated with the translation of these findings for the management of cervical cancer. The book is supplemented with figures and tables to aid conceptual understanding.

The book is relevant for researchers, academicians, scientists, as well as medical students seeking to understand the fundamentals of cervical cancer based on environmental or genetic factors.

Discusses the role of HPV and microbiome in cervical cancer Provides up-to-date epigenetic change detection techniques and their clinical implications Supplemented with ample figures and tables

Autorentext

Dr. Shama Prasada Kabekkodu is a professor at the department of cell and molecular biology, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India. He completed his Ph.D. in cancer epigenetics from the Manipal Academy of Higher Education (MAHE). Dr. Kabekkodu s areas of interest include functional epigenetics, cancer biology, and signaling. He has published several papers in peer-reviewed national and international journals, some book chapters, and has a few patents to his credit. Dr. Kabekkodu is a lifetime member of the Society of Biological Chemists, India, and the Society for Mitochondrial Research and Medicine-India.

Dr. Aniruddha Chatterjee is an associate professor at the department of pathology, Dunedin School of Medicine, University of Otago, New Zealand. He obtained his Ph.D. from the University of Otago, New Zealand. Dr. Chatterjee s areas of interest include epigenetics, molecular biology, and the bioinformatic analysis of next-generation sequencing data. He has published several papers in peer-reviewed national and international journals.

Dr. Sanjiban Chakrabarty is an associate professor at the department of public health genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India. He completed his Ph.D. in human genetics from Manipal Academy of Higher Education (MAHE), Manipal, India; and worked as a postdoctoral fellow at the Erasmus University Medical Center, Rotterdam, the Netherlands, Europe. Dr. Chakrabarty s areas of interest include cancer genomics, mitochondrial biology, and DNA damage response. He has published several papers in peer-reviewed national and international journals and has a few patents to his credit.

Inhalt

.- Chapter 1: Introduction to Cervical Cancer
.- Chapter 2: Epigenetic Mechanisms and Functions
.- Chapter 3: HPV As an Inducer of Epigenetic Changes in Cervical Cancer
.- Chapter 4: Microbiome and Epigenetic Interactions in Cervical Cancer
.- Chapter 5: Role of DNA Methylation in Cervical Cancer
.- Chapter 6: Chromatin Remodelling in Cervical Tumour Cells Regulates Proangiogenic Genes
.- Chapter 7: Role of miRNAs in Cervical Cancer
.- Chapter 8: Contribution of Long Noncoding RNAs and Other Noncoding RNAs in Cervical Cancer
.- Chapter 9: Methods to Detect Epigenetic Changes
.- Chapter 10:Role of Epigenetics in Cervical Cancer Radiotherapy Treatment Outcomes
.- Chapter 11:Epigenetic Therapy in Cervical Cancer.