Epigenomics

Epigenomics, an exciting and rapidly burgeoning new field, tells us how the genome works. But rather than merely describe epigenomes, this text focuses on exploring how understanding epigenomes tells us more about how biological systems work.

Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.

The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.

The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.

Epigenomics tells us how the genome works Characterising the epigenome is the next big step after determining the sequence of the genome Epigenetic influences are major causes of disease The epigenome is dynamic and can change in response to both intrinsic and extrinsic cues

Inhalt
Epigenomic Technologies and Analytical Approaches.- Strategies for Epigenome Analysis.- Sequencing the Epigenome.- Integrating Epigenomic Results.- Visualising the Epigenome.- Roles of DNA, RNA and Chromatin in Epigenomics.- The Expanding View of Cytosine Methylation.- Structural and Biochemical Advances in Mammalian DNA Methylation.- Epigenetic Profiling of Histone Variants.- Epigenetic Phenomena and Epigenomics in Maize.- Epigenetic Silencing of Pericentromeric Heterochromatin by RNA Interference in Schizosaccharomyces pombe.- Describing Epigenomic Information in Arabidopsis.- Role of Small RNAs in Establishing Chromosomal Architecture in Drosophila.- MacroRNAs in the Epigenetic Control of X-Chromosome Inactivation.- Epigenetic Control of Developmental Processes.- Polycomb Complexes and the Role of Epigenetic Memory in Development.- Genomic Imprinting A Model for Roles of Histone Modifications in Epigenetic Control.- The Epigenomic Landscape of Reprogramming in Mammals.- Epigenetic Gene RegulationLessons from Globin.- Meiotic Silencing, Infertility and X Chromosome Evolution.- The Epigenome in Health and Disease.- Genome Defense: The Neurospora Paradigm.- Integrating the Genome and Epigenome in Human Disease.- A Changing Epigenome in Health and Disease.- Cancer Epigenomics.- Epigenetic Modulation by Environmental Factors.- The Relevance of Epigenetics to Major Psychosis.