Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products

This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing Good Health and Well-Being, which is one of The Sustainable Development Goals (SDGs) 2030".

One of the pioneer collections on herbal medicines and therapies against coronavirus disease Covers strategies and approaches for discovering potential candidates for anti-SARS-CoV-2 drugs Includes discovering anti-SARS-CoV-2 compounds from plants, microorganisms and marine organisms

Autorentext

Jen-Tsung Chen is a professor of cell biology at the National University of Kaohsiung in Taiwan. He also teaches genomics, proteomics, plant physiology, and plant biotechnology. Dr. Chen's research interests include bioactive compounds, chromatography techniques, plant molecular biology, plant biotechnology, bioinformatics, and systems pharmacology. He is an active editor of academic books and journals to advance the exploration of multidisciplinary knowledge involving plant physiology, plant biotechnology, nanotechnology, ethnopharmacology, and systems biology. He serves as an editorial board member in reputed journals, including Plant Methods, GM Crops & Food, Plant Nano Biology, Biomolecules, International Journal of Molecular Sciences, and a guest editor in Frontiers in Plant Science, Frontiers in Pharmacology, Journal of Fungi, Current Pharmaceutical Design. Dr. Chen published books in collaboration with Springer Nature, CRC Press/Taylor & Francis Group and he is handling book projects for some more international publishers on topics of drug discovery, nanotechnology, bioengineering, plant functional genomics, and CRISPR-based plant genome editing.

Inhalt

1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments.- 2. The recent development of therapeutic strategies against COVID-19.- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity.- 4. Herbal formulations in fighting against the SARS-CoV-2 infection.- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2.- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection.- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2.- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection.- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2.- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence.- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19.- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19.- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function.- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis.- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2.- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection.- 17. Antiviral properties of South Indian plants against SARS-CoV-2.- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19.- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa.- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects.-