Evaluation the Diagnostic Value of CXCL-13 & anti-CarP with RF & ACCP

The study revealed a highly significant difference of CXCL13, Anti-CarP, Anti-CCP, and RF levels between RA patients and controls at p value =0.000. CXCL13 demonstrated good specificity (83%) and high sensitivity (93%) for RA patients, while Anti-CarP antibodies demonstrated low sensitivity(39%) and high specificity(98%) for diagnosis of RA. Patients with RA have positivity of 71.7% and 36.7% for RF and Anti-CarP, respectively, while healthy group have 11.7% and 1.7% respectively. The serum levels of CXCL13, anti-CarP and ACCP did not significantly correlate with DAS28-ESR and CDAI, indicating that these biomarkers are not effective in predicting the activity of RA.

Autorentext

I am an immunologist, with a PhD degree in medical microbiology, immunology and a member of the teaching staff (Assistant Professor) of the Department of Medical Microbiology/College of Medicine/University of Kufa.