Exosome Complex

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Details

The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions. The core of the exosome contains a six-membered ring structure to which other proteins are attached. In eukaryotic cells, the exosome complex is present in the cytoplasm, nucleus and especially the nucleolus, although different proteins interact with the exosome complex in these compartments regulating the RNA degradation activity of the complex to substrates specific to these cell compartments. Substrates of the exosome include messenger RNA, ribosomal RNA, and many species of small RNAs. The exosome has an exoribonucleolytic function, meaning it degrades RNA starting at one end (the so-called 3 end in this case), rather than cleaving the RNA at specific sites within the molecule.

Weitere Informationen

  • Allgemeine Informationen
    • GTIN 09786130713898
    • Editor Frederic P. Miller, Agnes F. Vandome, John McBrewster
    • EAN 9786130713898
    • Format Fachbuch
    • Titel Exosome Complex
    • Herausgeber Alphascript Publishing
    • Anzahl Seiten 132
    • Genre Biologie

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