Experimental Murine Asthma

Helminthic infections and allergic disorders including asthma, rhinitis and eczema are major public health problems. While helminthic infections are prevalent mainly in developing countries, allergic disorders are more common in developed industrialized ones. This has lead to the assumption that helminth infections protect against allergy. Studies in experimental animals have shown that infections with some helminths or immunization with helminth derived products suppress the development of allergic diseases. The suppressive effect of helminths has been attributed to the induction of regulatory network governed by cytokines such as IL-10 and TGF-beta, as well as Tregs and suppressor macrophages. This has raised the interesting idea that helminths may bear molecules that have potential therapeutic action against allergies and possibly other inflammatory diseases. The present study aims at comparative evaluation of suppressive effects of helminthic derived products on development of asthma in a murine model.

Autorentext

Born in Cairo, Egypt in 1959.Graduated from the Faculty of Medicine, Ain Shams University, Cairo, Egypt in 1983.Joined the Parasitology Department at the same faculty since 1987.Professor of Parasitology since 2005.Supervised several M.Sc and M.D thesis.Published 30 research articles in national and international journals.