Expression of p53, Cyclin-D1 & EGFR in oral squamous cell carcinoma

Oral cancer pathogenesis is a complex process involving genetic alteration during multistep carcinogenesis, growth regulation, apoptosis, immortalization, angiogenesis, invasion and metastasis. Molecular markers such as p53, Cyclin-D1 and EGFR regulate cell cycle and play important role in tumor progression and development. The present study evaluates the expressions of these molecular markers & its prognostic significance with treatment response in oral cancer patients undergoing chemoradiation. The strong positive expressions of p53, Cyclin-D1 and EGFR showed significantly lower survival as compared to negative or moderate positive expressions. Hence, expression of p53, Cyclin-D1 and EGFR may serve as a prognostic marker in oral cancer patients.

Autorentext

Seema Gupta works as Associate Professor in Department of Radiation Oncology, King George's Medical University, Lucknow. She has research experience of 10 years and published more than 30 papers in reputed journals. She is recognized for her excellence and innovative work in Head and Neck Cancer including molecular oncology of oral cancer.