Factor V Leiden in Ischaemic Heart Disease

Thrombosis is a major mechanism of cardiovascular disease and is a leading cause of death. Thrombosis generally occurs in the setting of imbalance in haemostatic regulation favoring blood clot formation. Activated protein C (APC) is a naturally circulating anticoagulant protein in plasma, which exerts its effects mainly by breaking down activated factor V in the coagulation cascade. A single point mutation in the coagulation factor V gene (FV R506Q) renders factor V resistant to inactivation by APC. The frequency of this mutation is known to be significantly increased in patients with thrombophilia. The influence of factor V Leiden mutation on the risk of arterial thrombosis has been the topic of this investigation. Numerous studies showed a strong correlation between APC-resistance, factor V Leiden mutation and venous thrombosis, whereas the relationship between these defects and the arterial thrombosis are controversial.

Autorentext

Dr. Abeer Mahmoud Badr, Prof. Dr. Somaya El Deeb, Dr. Dalia Yehya Kadry (authors of Cairo University), one of our research field is to assess the importance of some markers as possible prognostic markers in various hematological malignancies.