Fatty acids and experimental hepatitis

Hepatitis caused by virus infection, alcohol, bacteria and many hepatotoxic agents is known to be a serious clinical syndrome that could result in hepatocytes necrosis.Various models of experimental hepatitis are used; one of which is that induced by D-Galactosamine (D-GalN) .This model is identical to human viral hepatitis in both morphological and functional characters.Lipopolysaccharide (LPS) together with D-galactosamine (D-Ga1N) induce pronounced secretion of pro-inflammatory mediators by Kupffer cells which have been proved to be early hepatic injury stimulators . Omega-3 (n-3) represents a big family of fatty acids (essential fatty acids) that consists of eicosapentaenoic acid (EPA), -linolenic acid (ALA) and docosahexaenoic acid (DHA) .Omega-3 and omega-6 have the ability to modulate immune system components (production, releasing and activity), therefore omega -3 was found to have anti-inflammatory role while omega -6 is characterized by a pro-inflammatory effect. Different mechanisms were suggested in this point including prostaglandin production, cell membrane fluidity and regulation of gene expression .

Autorentext

Jihan Seid Hussein , Professor de Bioquímica Médica, Centro Nacional de Investigação, Giza, Egipto. Membro de várias sociedades científicas internacionais, recebeu um prémio de incentivo científico em Biotecnologia do Centro Nacional de Investigação em 2011. Recebeu um Prémio de Excelência Científica para os anos 2009-2016 ,Mais de 100 trabalhos internacionais.