Flow Transport Phenomena in Tissue Engineering

The dynamic environment in bioreactors is known to
affect tissue development in vitro. Chondrocytes,
the building blocks of articular cartilage, for
example, are stimulated by mechanical stresses such
as shear. On the other hand, high shear can damage
cells. Therefore, the optimization of bioreactor
design and operating conditions necessitates the
control of the shear stress environment. This book
focuses on the formulation of relationships between
tissue growth and the local shear stress in the
context of the tissue engineering of cartilage in
spinner-flask bioreactors. The analysis consists of
the characterization of the flow in a model
bioreactor, the measurement of glycosaminoglycan
synthesis in a prototype bioreactor operating under
similar hydrodynamic conditions, and the correlation
between the local shear stress and tissue deposition
on the cartilage constructs. This book provides new
insights into the contribution of convective flow
transport phenomena to cartilage development in
vitro, and should be especially useful to
bioengineers, students or anyone else who may be
interested in biofluids, tissue engineering or
mechanobiology.

Autorentext

Philippe Sucosky, PhD. Studied Mechanical Engineering at Ecole Nationale Supérieure d'Arts et Métiers (France) and Georgia Institute of Technology (Atlanta, GA). Assistant Professor in Aerospace and Mechanical Engineering, and Director of the Multi-Scale Cardiovascular Bioengineering Laboratory, University of Notre Dame (Notre Dame, IN).

Klappentext

The dynamic environment in bioreactors is known to affect tissue development in vitro. Chondrocytes, the building blocks of articular cartilage, for example, are stimulated by mechanical stresses such as shear. On the other hand, high shear can damage cells. Therefore, the optimization of bioreactor design and operating conditions necessitates the control of the shear stress environment. This book focuses on the formulation of relationships between tissue growth and the local shear stress in the context of the tissue engineering of cartilage in spinner-flask bioreactors. The analysis consists of the characterization of the flow in a model bioreactor, the measurement of glycosaminoglycan synthesis in a prototype bioreactor operating under similar hydrodynamic conditions, and the correlation between the local shear stress and tissue deposition on the cartilage constructs. This book provides new insights into the contribution of convective flow transport phenomena to cartilage development in vitro, and should be especially useful to bioengineers, students or anyone else who may be interested in biofluids, tissue engineering or mechanobiology.