Formation of the Heart and its Regulation

The Formation of the Heart and its Regulation reviews in considerable detail the major events in heart development and their control via genes, cell-cell interactions, growth factors and other contributing elements. In addition, there is an extensive and useful overview of the field of heart development taken as a whole. The book will appeal to all students and researchers working on cardiovascular development and to pediatric cardiologists.

Inhalt

1. Overview of Heart Development.- 2. Myofibrillogenesis in the Heart.- 3. Cardiac Looping and the Left-Right Axis: Integrating Morphologic, Molecular, and Genetic Analyses ofVertebrate Left-Right Asymmetry.- 4. Differentially Expressed Genes and Cardiac Morphogenesis.- 5. Molecular Mechanisms of Cardiac Diversification.- 6. Neural Crest and Heart Development.- 7. Cardiac Conduction System Development.- 8. The Epicardium and the Formation of the Coronary Vasculature.- 9. The Role of the Extracellular Matrix and Its Receptors in Modulating Cardiac Development.- 10. Growth Factor Regulation of Embryonic, Fetal and Neonatal Cardiac Development.- 11. Transforming Growth Factor-13 Signal Transduction in the Atrioventricular Canal During Heart Development.- 12. Homocysteine and the N-Methyl-D-Aspartate (NMDA) Receptor: Are They Keys to Conotruncal Abnormalities?.- 13. Function and Biomechanics of Developing Cardiovascular Systems.