Free Base (Chemistry)

Freebase or free base refers to the pure basic form of an amine, as opposed to its salt form. The amine is usually an alkaloid natural product. Free base is commonly used in chemistry and pharmaceuticals to describe the unprotonated amine form of a compound. Most alkaloids are unstable in their pure form and are often stored as salts. The salts usually exhibit greater water solubility. Common counterions include chloride, bromide, acetate and oxalate. Because of the ubiquity of chloride salts, formed from the reaction of the amine with hydrochloric acid, these amine derivatives are known as the hydrochlorides. For example, compare the free base hydroxylamine (NH2OH) with hydroxylamine hydrochloride (NH3OH+ Cl-)

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Freebase or free base refers to the pure basic form of an amine, as opposed to its salt form. The amine is usually an alkaloid natural product. Free base is commonly used in chemistry and pharmaceuticals to describe the unprotonated amine form of a compound. Most alkaloids are unstable in their pure form and are often stored as salts. The salts usually exhibit greater water solubility. Common counterions include chloride, bromide, acetate and oxalate. Because of the ubiquity of chloride salts, formed from the reaction of the amine with hydrochloric acid, these amine derivatives are known as the hydrochlorides. For example, compare the free base hydroxylamine (NH2OH) with hydroxylamine hydrochloride (NH3OH+ Cl-)