Garner s aldehyde

Chiral amino aldehydes are remarkable, as their aldehyde groups can be converted into a wide range of structural frameworks are the intermediates in several important industrial processes. However, the characteristic reactivity of amine and aldehyde functionalities is a major task in case of preparation and synthetic efficacy of -amino aldehydes as nitrogen protection assists undesired epimerization processes. Fischer's discovery of glucosamine in 1902 in which unprotected amine and aldehyde functionalities are stabilized as a cyclic hemiacetal is the first example of unprotected -amino aldehydes. Later on, he also synthesized glycinal, which was characterized through degradation studies due to its inherent instability via self-condensation. The probability for intramolecular stabilization of -amino aldehydes is not significant but the presence of incompatible functional groups make these unstable and hence, suitable N-and C-protection is vital.

Autorentext

Moumita Ghosh, travaille comme professeur adjoint à l'IITE de Gandhinagar, en Inde. Elle est chimiste inorganique. Elle est professeur adjoint à l'Université de Gujarat. Ses domaines de recherche sont la synthèse organique asymétrique, les structures organiques métalliques et les systèmes d'administration de médicaments.