Gene-Environment Interactions in Birth Defects and Developmental Disorders: Volume 152

Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including orofacial clefts, fetal alcohol spectrum disorders, autism, and others. The causes of individual cases of most common birth defects are unknown but likely involve a combination of genetic predisposition and environmental exposures. How these risk factors interact in the genesis of these conditions is still largely unknown and readers will find the latest information and ideas on these disorders, along with discussion of the challenges and opportunities for furthering knowledge in this area.

Autorentext
Robert J. Lipinski is an Associate Professor and Associate Chair of Comparative Biosciences and Associate Director of the Molecular and Environmental Toxicology program at the University of Wisconsin. He is also an Associate Editor for the American Journal of Medical Genetics and serves on the organizing committee for the David W. Smith Workshop on Malformations and Morphogenesis. His research program is focused on environmentally sensitive developmental mechanisms that regulate craniofacial morphogenesis. His research team has developed in vivo and advanced in vitro models that recapitulate molecular, cellular, and morphological aspects of human embryogenesis to identify genetic and environmental risk factors and investigate their interaction in causing birth defects.Robert S. Krauss is Mount Sinai Chair in Cell Biology; Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai; and a member of The Black Family Stem Cell Institute and Mindich Child Health and Development Institute. His work focuses on the mechanisms of early embryonic development and adult tissue regeneration. His laboratory uses a wide combination of approaches to gain insight into how genes and the environment interact in the causation of common birth defects, and how adult stem cells are called into action to repair injury to tissues. His lab has constructed accurate animal models for holoprosencephaly, a common and often devastating birth defect, leading to identification of genetic and environmental risk factors. In other work, his lab has identified factors critical to regulation of adult stem cells and muscle regeneration.

Inhalt

1. Gene-environment interactions in birth defect etiology: Challenges and opportunities
   Robert J. Lipinski and Robert S. Krauss
2. Transgenerational inheritance and its modulation by environmental cues
   Roxane Verdikt, Abigail A. Armstrong, and Patrick Allard
3. Gene-alcohol interactions in birth defects
   Joshua L. Everson and Johann K. Eberhart
4. The role of genes and environment in the etiology of congenital diaphragmatic hernias
   Nathan G. Burns and Gabrielle Kardon
5. Gene-environment interactions in the pathogenesis of common craniofacial anomalies
   Sharien Fitriasari and Paul A. Trainor
6. Gene×environment associations in orofacial clefting
   Mary L. Marazita
7. Gene-environment interactions underlying the etiology of neural tube defects
   Carlo Donato Caiaffa, Cristiane Sá Roriz Fonteles, Lei Yunping, and Richard H. Finnell
8. Gene×environment interactions in autism spectrum disorders
   Kimberly Keil-Stietz and Pamela J. Lein