General Anesthesia Research

This book explores several aspects of the research in the field of general anesthesia, including mechanisms of action of inhaled and intravenous hypnotic agents; the anesthetics-induced neurotoxicity in children and elderly; features and physiopathology of postoperative cognitive side effects; and findings from preclinical research focused on the recognition of potential links between anesthetics and cancer cell biology. Furthermore, chapters in this book cover technical topics such as preoperative monitoring of autonomic nervous activity; EEG based monitoring of general anesthesia; monitoring cerebral oximetry by near infrared spectroscopy; pharmacological issues of anesthesia interest; and optimization of perioperative course through the latest techniques such as the opioid-free anesthesia. Finally, this book offers a comprehensive and up-to-date discussion on the phenomenon of general anesthesia awareness and its potential psychological sequelae. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, General Anesthesia Research is a valuable resource for novice and expert anesthesiologists who want to learn more about the important advances made in this developing field.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
The Challenge of Accidental Awareness during General Anesthesia.- Impact of Anesthetics on Brain Electrical Activity and Principles of pEEG-Based Monitoring during General Anethesia.- Perioperative Monitoring of Autonomic Nervous Activity.- Monitoring Cerebral Oximetry by Near Infrared Spectroscopy (NIRS) in Anaesthesia and Critical Care: Progress and Perspectives.- Post-Traumatic Stress Disorder following Intraoperative Awareness.- Mechanisms of Action of Inhaled Volatile General Anesthetics: Unconsciousness at the Molecular Level.- Intravenous Hypnotic Agents: From Binding Sites to Loss of Consciousness.- Pharmacological Considerations for the Use of General Anesthetics in the Elderly.- Propofol Effects in Breast Cancer Cell Progression: Evidences from In Vitro Studies.- Postoperative Cognitive Function following General Anesthesia in Children.- The Challenge of Opioid-Free Anesthesia.- New Insights into the Pharmacology ofDexmedetomidine and Open Issues for Neurosurgical Procedures.- Transgenic Mouse Models, General Anesthetics and Alzheimer Disease: Findings from Preclinical Studies.- The Biochemical Basis of Delirium.- Postoperative Delirium and Postoperative Cognitive Dysfunction.