Genetic and Molecular Epidemiology of Multiple Myeloma

This exploration of the role of protein translation in multiple myeloma covers recent advances in oncogenomic research that further our understanding of the disease's molecular pathogenesis, and discusses the emerging technique of epigenetic gene silencing.

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma. This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.

Explores the role of protein translation in multiple myeloma Discusses epigenetic gene silencing as a new target for multiple myeloma immune surveillance Examines the cell cycle control of plasma cell differentiation Includes supplementary material: sn.pub/extras

Klappentext

This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment.

Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.

Inhalt
Preface.- Genetics of Multiple Myeloma.- Gene expression signature in MGUS and multiple myeloma.- Cap-Dependent Protein Translation Initiation in Multiple Myeloma: an Attractive Target for Therapy.- IRES-dependent, CAP-independent translation in Multiple Myeloma.- Epigenetic gene silencing as a new target for multiple myeloma.- Role of Bone Disease in the Pathogenesis of Multiple Myeloma.- Index.