Genetic Models of Down Syndrome

Down syndrome is a textbook example of a chromosomal disorder and is common, occurring in 1 in 700 live births in the US. While there are many books previously published on the genetics of Down syndrome, and many studies in diverse species, this is the first book of its kind on the research models for Down syndrome that covers animal models. This book offers an in-depth introduction and discussion of the genetic models of down syndrome across diverse species, including rodents, zebrafish, drosophila, and human organoids. Authors use a cross-cutting approach to compare the strengths and weaknesses of each model system, explore how to use model organisms to study human diseases, and capture the status of the field. This book is a useful resource for biomedical researchers and students interested in using model systems to study Down syndrome and learn about Down syndrome and other chromosomal disorders.

The first book of its kind to explore the research models for Down syndrome across diverse species Features chapters on rodent, Drosophila, C. elegans, zebrafish, and human organoid models Uses a cross-cutting approach to present the strengths and weaknesses of each model system of down syndrome

Autorentext

Bing Ye, PhD, is the Burton L. Baker Collegiate Professor of the Life Sciences at the University of Michigan Life Sciences Institute, and Professor of Cell and Developmental Biology at the University of Michigan Medical School. The focus of his lab's research is to address: how neuronal development contributes to the assembly and function of the nervous system, and how defects in this process lead to brain disorders. The Ye Lab uses both Drosophila and mice in their research, and take a multi-disciplinary approach that includes genetics, cell biology, developmental biology, biochemistry, advanced imaging (for neuronal structures and activity), electrophysiology, computation, and behavioral studies.

Inhalt

Chapter 1: Introduction.- Chapter 2 : Rodent Models of Down Syndrome I: Mouse & Rat.- Chapter 3: Rodent Models of Down Syndrome II: Mouse.- Chapter 4: Rodent Models of Down Syndrome III: Mouse.- Chapter 5: Modeling Down Syndrome in C. elegans.- Chapter 6: Modeling Down Syndrome in Drosophila.- Chapter 7: Zebrafish Models of Down Syndrome.- Chapter 8: Using Human Brain organoids to Study Down Syndrome.- Chapter 9: Cellular Models: Stem Cells and other Cellular Models.-Chapter 10: Conclusions and Perspectives.