Ghrelin in Health and Disease

Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical to controlling food intake and energy balance. This overview of ghrelin in physiology and as a modulator of function covers all the molecular and clinical issues.

Superb overview of the relevance of ghrelin to physiology and as a modulator of function. Covers all of the molecular and clinical issues, providing basic translational research on ghrelin with results of clinical investigations Advances our clinical understanding of obesity, growth, and reproductive pathogenesis Authored by leading international investigators in the field

Inhalt

Ghrelin: A History of Its Discovery.- Enzymatic Processing of Ghrelin Precursor.- Ghrelin's Novel Signaling in Islet b-Cells to Inhibit Insulin Secretion and Its Blockade As a Promising Strategy to Treat Type 2 Diabetes.- Gastric Ghrelin in the Regulation of Appetite and Metabolism.- Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues.- Ghrelin: Neuropeptide Regulator of Metabolism.- GOAT and the Regulation of Energy and Glucose Homeostasis.- Ghrelin Regulation of Sleep, Circadian Clock and Body Temperature.- Ghrelin Regulation of Learning, Memory and Neurodegeneration.- Ghrelin Antagonism: A Potential Therapeutic Target for Addictive Behavior Disorders.- Ghrelin Receptor Agonists in Cachexia of Human Aging.- Use of Ghrelin and Ghrelin Receptor Agonists in Cancer- and Chemotherapy-Induced Cachexia.- Ghrelin in Cachexia Associated with End-Stage Renal Disease.- Ghrelin Suppression of Autoimmune Encephalomyelitis.- Physiological Roles of Des-Acyl Ghrelin.