Glycobiology and Medicine

This book contains the Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, held 14-17 September, 2002, in Seillac, France.
This book highlights the latest developments in glycoimmunology, including glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease.

Inhalt

• Glycosylation Dependent Bacterial Infections. 1. A Sweet Coating - How Bacteria Deal With Sugars; A.P. Corfield, R. Wiggins, C. Edwards, N. Myerscough, B.F. Warren, P. Soothill, M.R. Millar, P. Horner. 2. The Glycosylation of Airway Mucins in Cystic Fibrosis and its Relationship with Lung Infection by Pseudomonas aeruginosa; P. Roussel, G. Lamblin. 3. Structural Basis of Bacterial Adhesion in the Urinary Tract; J. Berglund, S.D. Knight.
• Glycosylation Dependent Viral Infections. 4. Crystal Structure of an Intact Human IgG: Antibody Asymmetry, Flexibility, and a Guide for HIV-1 Vaccine Design; E. Ollmann Saphire, R.L. Stanfield, M.D.M. Crispin, G. Morris, M.B. Zwick, R.A. Pantophlet, P.W.H.I. Parren, P.M. Rudd, R.A. Dwek, D.R. Burton, I.A. Wilson.
• Inflammation. 5. Remnant Epitopes Generate Autoimmunity. From Rheumatoid Arthritis and Multiple Sclerosis to Diabetes; F.J. Descamps, P.E. Van den Steen, I. Nelissen, J. Van Damme, G. Opdenakker. 6. Endothelial Cell Glycosylation: Regulation and Modulation of Biological Processes; C. Kieda, D. Dus. 7. Involvement of GAGs in the Activity of Pro-inflammatory Factors; F. Allain, C. Vanpouille, A. Denys, R. Pakula, M. Carpentier, J. Mazurier. 8. Lectin Domains on Cytokines; J.-P. Zanetta, G. Vergoten. 9. Cytokines and Glycosaminoglycans (GAGs); R.V. Gibbs.
• Glycopathology. 10. Thomsen-Friedenreich Antigen: The "Hidden" Tumour Antigen; S. Goletz, Y. Cao, A. Danielczyk, P. Ravn, U. Schoeber, U. Karsten. 11. Glycodynamics of Mucin Biosynthesis in Gastrointestinal Tumour Cells; I. Brockhausen. 12. O-GlcNAc Glycosylation and Neurological Disorders; T. Lefebvre, M.-L. Caillet-Boudin, L. Buée, A. Delacourte, J.-C. Michalski.
• Congenital Defects in Glycosylation. 13. The Carbohydrate Epitope of the Neutralizing anti-HIV-1 Antibody 2G12; C.N. Scanlan, R. Pantophlet, M.R. Wormald, E. Ollmann Saphire, D. Calarese, R. Stanfield, I.A. Wilson, H. Katinger, R.A. Dwek, D.R. Burton, P.M. Rudd. 14. New Therapeutics for the Treatment of Glycosphingolipid Lysosomal Storage Diseases; T.D. Butters, R.A. Dwek, F.M. Platt.
• Glycoimmunology. 15. Mannose-Binding Lectin (MBL) Route for Activation of Complement; M. Kojima, J.S. Presanis, R.B. Sim. 16. Anti-inflammatory Properties of Specific Glycoforms of Human &agr;1 Acid Glycoprotein; W. Van Dijk, D.C.W. Poland. 17. The Glycosylation of Tyrosinase in Melanoma Cells and the Effect on Antigen Presentation; S.M. Petrescu, C.I. Popescu, A.J. Petrescu, R.A. Dwek. 18. Glycobiology of the Rheumatic Diseases: An Update; A. Alavi, J.S. Axford.