Growth, Proliferation, and Apoptosis in Hepatocytes

To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apoptosis was selected as the theme of the 12th Yamaguchi Symposium on Liver Diseases. Ten leading researchers presented their latest experimental results. Focusing on apoptosis, guest speaker Professor D.A. Brenner, USA, spoke on the regulation of tumor necrosis factor alpha and Fas ligand-induced hepatic apoptosis by nerve factor-kappa B. Other researchers covered the molecular basis for clonal deletion therapy in hepatocellular carcinoma, hepatitis C virus induction of proliferation signals, helix-loop-helix protein in liver-specific gene expression, and reconstitution of hepatic tissues using liver stem cells, among other topics of current interest. These proceedings thus serve as a useful resource for all involved in hepatology research.

Inhalt

1. HHM: a dominant inhibitory helix-loop-helix protein associated with liver specific gene expression and liver stem cell.- 2. Expression of Musashi-1 antigen (a neural stem cell RNA-binding protein in the liver tissues of patients with hepatitis).- 3. Reconstitution of hepatic tissues using liver stem cells.- 4. Regulation of TNFalpha- and Fas-induced hepatic apoptosis by NF-kB.- 5. Retinoid-induced Apoptosis in Hepatocellular Carcinoma: A Molecular Basis for 'Clonal Deletion' Therapy.- 6. Signal transduction involved in cell cycle regulation of normal hepatocyte and hepatoma cells.- 7. Effects of Simultaneous Treatment with Growth Factors on DNA Synthesis, MAPK Activity, and G1 Cyclins in Rat Hepatocytes.- 8. Involvement of p21WAF1/Cip1 and p27Kip1 in Troglitazone-induced Cell Cycle Arrest in Human Hepatoma Cell Lines.- 9. Role of Fas Ligand in Immune Pathogenesis of Hepatocellular Carcinoma.- 10. Induction of Proliferation-related signals by the Hepatitis C Virus.