Hand transplantation

Hand transplantation was the dream of humanity until 1998, when a group of international surgeons gathered in Lyon performed the first of many hand transplantations carried out since then. This book presents the global international experimental and clinical experience on limb transplantation and other composite tissue allografts. It represents the most complete and comprehensive review of all aspects of this innovative and groundbreaking procedure. They range from the experimental basis of hand transplantation, to surgical techniques, to immunology and antirejection drug strategies, to the presentation of the current functional results and future directions, including the possibility to introduce face and uterus transplantation to the clinical practice. This book represents a milestone in the medical literature and is a great asset for every scientific library.

Represents the most complete and comprehensive review on the global international experimental and clinical experience on hand transplantation and other composite tissue allografts Contains over 150 images on operative and postoperative phases Displays the most updated performances, such as the first face transplantation

Zusammenfassung

This book presents international experimental and clinical experience on limb transplantation and other composite tissue allografts, representing the most complete and comprehensive review of this innovative and ground breaking procedure. This book is a milestone in medical literature and an asset for every scientific library.

Inhalt
Historical Remarks.- Cosmas and Damian Revisited.- Hand Transplantation as an Evolution of Microsurgery: A Logical Step Towards Better Reconstructive Options.- Experimental Limb Transplantation.- Hind-Limb Transplantation in the Rat: Surgical Technique, Anaesthesia and Early Postoperative Management.- Indefinite Survival and Functional Recovery of Limb Allografts in Rodents.- Induction of High-Level Chimerism in Composite Tissue Transplants.- Simultaneous Vascularised Bone Marrow Transplantation to Promote Acceptance of Limb Allografts.- Experimental Approaches to Composite Tissue Allograft Transplants.- A Review of Current Strategies to Achieve Tolerance in Animal Models.- The History of Experimental Hand Transplantation in Primates.- Hand Transplantation in Monkeys: Technical Details and Immunological Aspects.- Ethics and Medico-Legal Implications.- Ethical Aspects of Non-Life-Saving Allografts with Special Regard to the Hand.- Ethical Issues of Organ Transplantation in Non-Life-Saving Situations.- Informed Consent, Medico-Legal Implications, Public and Private Insurance Issues and Quantification of Disability in Hand Transplantation.- Living with Two Different Fingerprints: Legal Implications and Identification Issues.- Organization of Hand Transplantation.- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation: The Lyon Experience.- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation:The Milan Experience.- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, ClinicalTrial Organisation, Staff Requisites for Hand Transplantation: The Innsbruck Experience.- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation: The Brussels Experience.- Patient Management and Follow-up.- Surgical Technique of Hand Transplantation.- Instruments, Sutures and Needles for Hand Transplantation.- Anaesthetic Management.- Harvesting the Hand.- Preparing the Recipient.- Technical and Surgical Details of Hand Transplantation.- Hand Replantation and Transplantation: More Differences than Similarities.- Immunology of Hand Transplantation.- Current Concepts.- Immunosuppressive Therapy.- Induction and Maintenance Therapy.- Side-Effects and Potential Complications.- CMV Infection and Reactivation.- Specific T-Cell Response to HCMV Infection.- Ocular Complications after Hand Transplantation.- Limb Rejection and Monitoring.- Skin Rejection in Human Hand Allografts: Histological Findings and Grading System.- Pharmacological Treatment of Rejection.- Monitoring Rejection with a Distant Sentinel Skin Graft.- Functional Recovery of Transplanted Hands.- Bone Healing in Hand Transplantation.- Return of Sensibility and Motor Recovery of Extrinsic and Intrinsic Muscles.- From Silent Neuroma to Reactivation of Axonal Growth: How a Peripheral Nerve can Start to Regenerate into a Transplanted Hand?.- Modified Visual Feedback in Rehabilitation.- Analysis of Motor Unit Reinnervation in Muscles of the Transplanted Hand.- Role of the Sympathetic Nervous System on Arterial Distensibility.- An Instrumental Kit for a Comprehensive Assessment of Functional Recovery.- Human Brain Plasticity after Bilateral Hand Allograft.- The Sensor Glove in Preoperative Conditioning and Postoperative Rehabilitation.- A Comprehensive Functional Score System in Hand Transplantation.- Quality of Life in Hand Transplant Patients.- Psychological Issues in Hand Transplantation.- Psychological Evaluation and Patient's Profile.- Hand Transplant and Body Image.- Psychological Effects of Hand Transplantation.- Other Composite Tissue Transplant.- Allogeneic Vascularised Knee Transplantation.- Laryngeal Transplantation.- Uterus Transplantation.- Abdominal Wall Transplantation: A Review of the Literature.- First Human Face Allograft: Report at 4 months.- Lower-Extremity Hindquarter Transplantation in Conjoined Twins.- Future Directions.- Limb Transplantation in Congenital Deformities.- Mechanisms Involved in the Induction of Tolerance in Allogeneic Hand Transplantation: A Proposal.- Induction of Tolerance in Allotransplantation.- The International Registry on Hand and Composite Tissue Transplantation (IRHCTT).- The International Registry on Hand and Composite Tissue Transplantation (IRHCTT).- An Extensive Bibliography on Hand Transplantation.- An Extensive Bibliography on Hand Transplantation.