Handbook of Platelet Physiology and Pharmacology

Handbook of Platelet Physiology and Pharmacology represents the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology and function. This edited volume provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an excellent overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials.
Handbook of Platelet Physiology and Pharmacology will prove a useful reference for hematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

Klappentext

Handbook of Platelet Physiology and Pharmacology represents the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology and function. This edited volume provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an excellent overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials. Handbook of Platelet Physiology and Pharmacology will prove a useful reference for hematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

Inhalt

1. Platelet Physiology & Pharmacology: An overview.- Receptor Biology.- 2. Human Platelet Thrombin Receptors and the two Receptor Model for Platelet Activation.- 3. Platelet Thromboxane Receptors: Biology and Function.- 4. Collagen Receptors: Biology and Functions.- 5. Adenosine Receptors: Biology and Function.- 6. Platelet Activating Factor and Platelets.- 7. Platelet Glycoprotein lb-V-lX: Biology and Function.- 8. Fibrinogen Receptors: Biology and Function.- Platelet Biochemistry.- 9. Biochemistry of Platelet Activation.- 10. GTP Binding Proteins in Platelets.- 11. Platelet Cyclic Nucleotide Phosphodiesterases.- 12. Polyenoic Fatty Acids and Platelet Function.- 13. Phospholipase A2 in Platelets.- Experimental Physiology.- 14. Platelet Biorheology: Adhesive Interactions in Flow.- 15. Platelet Vessel Wall Interactions.- 16. Platelet-Biomaterial Interactions.- 17. Comparative Physiology of Platelets from Different Species.- Platelet Pathology.- 18. The Molecular Pathology of Glanzmann's Thrombasthenia.- 19. Congenital Disorders of Platelet Signal Transduction and Secretion A.- 20. Biochemistry of Altered Platelet Reactivity in Hypertension.- Platelet Pharmacology.- 21. Nitric Oxide-mediated Regulation of Platelet Function.- 22. Aspirin, Prostaglandins and Platelet Function: Pharmacology and Thrombosis Prevention.- 23. Current Developments in Anticoagulant and Antithrombotic Agents.- 24. Randomized Trials of Antiplatelet Therapy.