Heart Rate and Rhythm

Heart Rate and Rhythm provides an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms.

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms.

Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Introduces into the molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms Written by experts from various fields Of interest for researchers in cardiac electrophysiology, cell biology, and pharmacology Includes supplementary material: sn.pub/extras

Inhalt
Normal Cardiac Rhythm and Pacemaker Activity.- Modeling of Rhythm in the Heart.- Cardiac Development and Anatomy.- Mechanisms of Acquired Arrhythmia.- Mechanisms of Inherited Arrhythmia.- Role of Specific Channels and Transporters in Arrhythmia.- Drugs and Cardiac Arrhythmia.