Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics

This book encompasses a decade of explosive growth in knowledge of the pathobiology of hematologic cancer, and offers the insight of experts from around the world on current treatment approaches and on future progress in malignant hematologic diseases.

In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer,as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.

Compiles new knowledge on pathobiology of hematologic cancer Gives comprehensive information on current treatments on malignant hematologic diseases Written by international leaders on the field

Inhalt

Preface.-1 B-Cell Growth, Differentiation and Malignancies .-2 Follicular Lymphoma: Recent advances.-3 Chronic Lymphocytic Leukemia: From Pathobiology to Targeted Therapy.-4 Genetic and Environmental Determinants in Multiple Myeloma: Implications for Therapy.-5 EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly.-6 HIV and Lymphoma.-7 Molecular Biology of Mantle Cell Lymphoma.-8 Pathogenesis of Non-Hodgkin Lymphoma Derived from Inflammatory, Autoimmune or Immunologic Disorders.-9 Pathogenesis of Non-Hodgkin Lymphoma Derived from Infection Diseases.-10 Hodgkin Lymphoma: From Molecular Pathogenesis to Targeted Therapy.-11 Myelodysplastic Syndromes.-12 Chronic Myeloproliferative Disorders: from Molecular Pathogenesis to Targeted Therapy.-13 Chronic Myeloid Leukemia.-14 Novel Targeted Therapeutics for Acute Myeloid Leukemia.-15 Novel Targeted Therapeutics for Peripheral T-Cell Lymphoma.-16 Large Granular Lymphocyte Leukemia From Molecular Pathogenesis to Targeted Therapy.-17 Epigenetic Regulation and Therapy in Lymphoid Malignancies.-Index.