Hematopoietic Stem Cell Transplantation

This book covers pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T-cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution.

The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Written by leading experts in the field of hematopoietic stem cell transplantation Serves as a reference text for those actively involved in research and clinical practice of hematopoietic stem cell transplantation Provides a current and succinct overview for laboratory scientists, oncologists, hematologists, fellows, residents and medical students in this field

Klappentext

Hematopoietic Stem Cell Transplantation reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution. The unique aspect to this volume is that each chapter is co-authored by experts in their respective fields from different institutions to provide potentially different perspectives on each topic. This book provides a very current and succinct overview of hematopoietic stem cell transplantation that is complimentary to the larger texts on the field.

"There have been dramatic advances in the application of hematopoietic stem cell transplantation for the treatment of malignant disease. This text provides a comprehensive update of the progress in the field. Technical and therapeutic innovations are reviewed by a distinguished assemblage of talented investigators." Steven T. Rosen, M.D., Series Editor

Inhalt
Principles and Overview of Allogeneic Hematopoietic Stem Cell Transplantation.- The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation.- Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation.- Advancement and Clinical Implications of HLA Typing in Allogeneic Hematopoietic Stem Cell Transplantation.- Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications.- Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation.- Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells.- Understanding and Enhancing the Graft-Versus-Leukemia Effect After Hematopoietic Stem Cell Transplantation.- Reduced-Intensity and Nonmyeloablative Conditioning Regimens.- Umbilical Cord Blood Transplantation.- Biology and Management of Acute Graft-Versus-Host Disease.- Biology and Management of Chronic Graft-Versus-Host Disease.- Radioimmunoconjugates in Hematopoietic Stem Cell Transplantation.- Evolving Indications for Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Other Plasma Cell Disorders.- Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin's Lymphoma.- The Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma.- Role of Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome.- Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia.- Hematopoietic Stem Cell Transplantation in Children and Adolescents with Malignant Disease.- Cellular Adoptive Immunotherapy After Autologous and Allogeneic HematopoieticStem Cell Transplantation.- Improvements in the Prevention and Management of Infectious Complications After Hematopoietic Stem Cell Transplantation.