Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist

Formatted to integrate the scientific basis of HSCT and ethical considerations into a relevant clinical framework

Features diagrams, illustrations, and tables that summarize key points and concepts for each chapter

Written by experts in the field

Autorentext
Valerie I. Brown, MD, PhD

Director, Experimental Therapeutics, Pediatric Hematology/Oncology

Director, Pediatric Hematology/Oncology Fellowship Program

Penn State Milton S. Hershey Medical Center and Children's Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA

Inhalt

Introduction.- Historical Overview of Pediatric HSCT.- Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT).- Pretransplantation: Indications and Timing.- Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia.- HSCT Recipient Pretransplantation Evaluation.- How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT.- Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation.- Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale.- Engraftment and Chimerism.- Graft Failure.- Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome.- Nutrition in the Peri-HSCT Period.- Mucositis and Pain in the Peri- HSCT Period.- Hepatoxicity in the Peri- HSCT Period.- Renal Toxicities in the Peri-HSCT Period.- Infectious Complications and HSCT.- Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment.- Chronic GVHD.- Hematologic Complications Associated with HSCT.- Pulmonary Complications Associated with HSCT.- Renal Complications Associated with HSCT.- Cardiac Complications Associated with HSCT.- Neurologic and Sensory Complications Associated with HSCT.- HSCT-Associated Complications of the Skin, Hair and Nails.- Immune Reconstitution after Hematopoietic Stem Cell Transplantation.- Life After HSCT: Survivorship and Long-Term Issues.- Medications commonly Used in Pediatric HSCT.