Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

With details of recent progress in HBOC research along with emerging products, this in-depth treatment surveys the scientific and clinical fundamentals. It evaluates the literature on safety and efficacy and predicts the most likely forthcoming advances.

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

Focus on Hemoglobin-based oxygen carriers (HBOCs) Up to date information on progress of existing products, new emerging products/technologies In-depth treatise covering rationale, scientific and clinical basis, ideal characteristics of HBOCs, approaches to HBOC products, scale up and manufacturing, preclinical and clinical studies for safety and efficacy evaluations, current challenges and future directions Includes supplementary material: sn.pub/extras

Inhalt
Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.