Heterocycles by Multicomponent reactions

Multi-component reactions (MCRs) are convergent reactions, in which three or more starting materials react to form a product, where basically all or most of the atoms contribute to the newly formed product (Figure 1). In an MCR, a product is assembled according to a cascade of elementary chemical reactions. Thus, there is a network of reaction equilibria, which all finally flow into an irreversible step yielding the product. The challenge is to conduct an MCR in such a way that the network of pre-equilibrated reactions channel into the main product and do not yield side products. The result is clearly dependent on the reaction conditions: solvent, temperature, catalyst, concentration, the kind of starting materials and functional groups. Such considerations are of particular importance in connection with the design and discovery of novel MCRs.

Autorentext

Le Dr Siddharth Sharma (chirurgie orale et maxillo-faciale) travaille actuellement comme professeur adjoint au Divya Jyoti College of Dental Sciences and Research.