Histamine in Inflammation

Since the discovery of histamine's many physiological functions, a rich body of research has uncovered roles for histamine in almost every physiological process. This volume provides a snapshot of the current understanding of histamine's role in just one important therapeutic area-inflammation.

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term antihistamine has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic areainflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Provides an overview of the pharmacology of the four histamine receptors and describes how histamine is synthesized and the insights derived from mice where this synthesis is disrupted Discusses the important role of histamine in neurotransmission and for the treatment of various neurological disorders Explains the future of antihistamine research and the potential for novel antihistamines targeting the newest members of the histamine receptor familythe H3 and H4 receptors

Autorentext

Robin L. Thurmond, PhD is a Compound Development Team Leader with the Clinical Research group at Johnson & Johnson Pharmaceutical Research & Development in La Jolla, California. Prior to that he was a Research Fellow with the Immunology Drug Discovery group at the same site. He received his BA in Chemistry from the University of Virginia and his PhD in Biochemistry from the University of Arizona. Dr. Thurmond studied membrane biophysics at the University of Arizona and worked on the molecular aspects of rhodopsin function during his postdoctoral training at the Massachusetts Institute of Technology with Dr. Gobind Khorana. He began his career with Johnson & Johnson in 1996 at the RW Johnson Pharmaceutical Research Institute in Raritan, New Jersey, and has been with Johnson & Johnson for over 14 years. Dr. Thurmond currently resides in San Diego, California.

Inhalt
One Hundred Years of Histamine Research.- Molecular Pharmacology of the Four Histamine Receptors.- Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice.- Histamine in Allergic Rhinitis.- The Role of Histamine in Ocular Allergy.- The Role of Histamine in Asthma.- Antihistamines in the Treatment of Urticaria.- Histamine and Antihistamines in Atopic Dermatitis.- Histamine, Immune Cells and Autoimmunity.- Histamine in Neurotransmission and Brain Diseases.- Histamine in Normal and Malignant Cell Proliferation.- The Future Antihistamines: Histamine H3 and H4 Receptor Ligands.