Histopathology of Preclinical Toxicity Studies

Informationen zum Autor MBChB, FRCPath, Consulting Pathologist and Honorary Senior Lecturer, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK Klappentext The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. Zusammenfassung Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation! including pathologists! toxicologists! and pharmacologists. Inhaltsverzeichnis Chapter 1: IntroductionChapter 2: Integumentary System - Skin and subcutaneous tissue Chapter 3: Mammary GlandChapter 4: Haemopoietic and Lymphatic Systems - Blood/bone marrow- Lymphoid system- Lymph nodes- Spleen- Thymus- Lymphoreticular neoplasms Chapter 5: Musculoskeletal System - Bone- Joints- Skeletal muscle Chapter 6: Respiratory Tract - Nose, nasal sinuses, nasopharynx and pharynx- Larynx and trachea- Bronchi and lungs Chapter 7: Cardiovascular System - Heart and pericardium- Systemic blood vessels- Pulmonary blood vessels Chapter 8: Gastrointestinal tract - Forestomach- Stomach (glandular)- Small intestine- Large intestine Chapter 9: Liver and Pancreas - Liver- Bile ducts, biliary system - Pancreas Chapter 10: Urinary System - Kidney- Urinary bladder Chapter 11: Male Genital Tract - Prostate gland- Epididymis- Testis Chapter 12: Female Genital Tract - Vagina- Cervix- Uterus- Ovary Chapter 13: Endocrine System - Pituitary gland- Adrenal gland- Thyroid gland- Parathyroid gland Chapter 14: Nervous System and Special Sense Organs - Brain- Spinal cord, spinal nerve roots, peripheral nerves- Eye- Ear Subject index ...

Autorentext
MBChB, FRCPath, Consulting Pathologist and Honorary Senior Lecturer, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK

Klappentext

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

Zusammenfassung
Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.

Inhalt

Chapter 1: IntroductionChapter 2: Integumentary System- Skin and subcutaneous tissueChapter 3: Mammary GlandChapter 4: Haemopoietic and Lymphatic Systems- Blood/bone marrow- Lymphoid system- Lymph nodes- Spleen- Thymus- Lymphoreticular neoplasmsChapter 5: Musculoskeletal System- Bone- Joints- Skeletal muscle Chapter 6: Respiratory Tract- Nose, nasal sinuses, nasopharynx and pharynx- Larynx and trachea- Bronchi and lungsChapter 7: Cardiovascular System- Heart and pericardium- Systemic blood vessels- Pulmonary blood vesselsChapter 8: Gastrointestinal tract- Forestomach- Stomach (glandular)- Small intestine- Large intestineChapter 9: Liver and Pancreas- Liver- Bile ducts, biliary system - PancreasChapter 10: Urinary System- Kidney- Urinary bladderChapter 11: Male Genital Tract- Prostate gland- Epididymis- TestisChapter 12: Female Genital Tract- Vagina- Cervix- Uterus- OvaryChapter 13: Endocrine System- Pituitary gland- Adrenal gland- Thyroid gland- Parathyroid glandChapter 14: Nervous System and Special Sense Organs- Brain- Spinal cord, spinal nerve roots, peripheral nerves- Eye- EarSubject index