Human and Mosquito Lysozymes

Malaria remains an alarming emergency in developing countries. It is thus urgent to identify any parasite or host molecules that can serve as new affordable markers for early diagnosis of disease complications or as new targets for vector control. In this context, human and mosquito lysozymes are good candidate molecules, as their involvement in malaria has been recently reported by several independent groups. This book reviews the grounded knowledge on malaria etiology and physiopathology, as well as the current approaches for diagnosis, therapy, and vector control. In addition, the emerging evidence on the involvement of human and mosquito lysozymes in malaria from available experimental models and clinical studies is thoroughly discussed, as is the potential use of other antimicrobial peptides against malaria. Intriguingly, the contributors propose that old well-known molecules such as lysozymes might be used as new targets for cost-effective strategies to fight malaria.

Covers groundbreaking research into new understandings and uses for older and well-known enzymes Explores both human and mosquito lysozymes and their medical potential Considers the potential role of other antimicrobial peptides, ie TEP-1 in the mosquito, and PF-4 in the human host Includes supplementary material: sn.pub/extras

Autorentext

Mauro Prato currently works as an Adjunct Professor of Biochemistry at the University of Torino, Italy. His research activity focuses on the involvement of proteolytic enzymes in malaria. His track-record includes 40 papers published by peer-reviewed journals, 1 book, 7 book chapters, 97 communications in well-established conferences, and 1 patent.

Inhalt
Etiopathogenesis and pathophysiology of malaria.- Malaria diagnosis, therapy, vaccines and vector control.- Lysozymes in the animal kingdom.- Role of lysozymes of Anopheles mosquitoes in Plasmodium development.- Effects of malaria products on human monocyte and neutrophil degranulation and lysozyme release.- Human lysozyme in malaria patients.- Beyond lysozyme.